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KDM5B Antibody - C-terminal region (ARP72851_P050)

KDM5B Antibody - C-terminal region (ARP72851_P050)

Item no.	ARP72851_P050
Manufacturer	AVIVA Systems Biology
Amount	100 ul
Category	Oncology Antibodies By Cell Type Carcinoma Hematology Leukemia Melanoma Sarcoma Western Blot Primary Antibodies
Type	Antibody Polyclonal
Format	Lyophilized powder
Applications	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	KDM5B, JARID1B, PLU1, RBBP2H1
Similar products	KDM5B, JARID1B, PLU1, RBBP2H1
Available
Gene symbol	KDM5B
Protein size	1544
Molecular weight	169kDa
Product format	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Gene id	10765
Reconstitution and storage	For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Partner proteins	FBXW11. UBC. HDAC2. HDAC4. SUMO1. SUMO3. PPP1CA. TFAP2C. MYC. HDAC7. HDAC5. NCOR1. PAX9. HDAC1. ELAVL1. CHD3. MTA3. MBD3. KDM1A. MTA2. MBD2. RBBP7. RBBP4. RB1. SUMO2. KLF10. LMO2. FOXG1. AR. VGLL3. PRDM13. ARID1B. BMP2K. RNF43. RBM15B. DBNL. CECR6. SLC39A
Description of target	KDM5B is a histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.
Purification	Affinity Purified
Clonality	Polyclonal
Immunogen	The immunogen is a synthetic peptide directed towards the C-terminal region of Human KDM5B
Drywet	Wet Ice

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 9/25/2025

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