HNRNPK Antibody

Polyclonal Antibody

Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies

50 kDa

HNRNPK

Liquid PBS (pH 7.4) 150mM NaCl, 0.02% sodium azide and 50% glycerol

One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.

Heterogeneous nuclear ribonucleoprotein K

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

The optimal working dilution should be determined by the end user.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.