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ITPR1 Antibody (Phospho-Ser1764)

ITPR1 Antibody (Phospho-Ser1764)

Item no.	OAAF00552
Manufacturer	AVIVA Systems Biology
Amount	100 ug
Category	Neuroscience Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Citations	Yamada N., Biochem. J. 302:781-790(1994). Harnick D.J., . Biol. Chem. 270:2833-2840(1995). Nucifora F.C. Jr., Brain Res. Mol. Brain Res. 32:291-296(1995).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ACV;CLA4;inositol 1,4,5-triphosphate receptor,type 1;inositol 1,4,5-trisphosphate receptor type 1;INSP3R1;IP3 receptor;IP3 receptor isoform 1;IP3R;IP3R 1;IP3R1;PPP1R94;protein phosphatase 1,regulatory subunit 94;SCA15;SCA16;SCA29;type 1 inositol 1,4,5-trisphosphate receptor;type 1 InsP3 receptor.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Applications	Enzyme-linked immunosorbent assay\|Immunofluorescence\|Immunohistochemistry\|Immunohistochemistry-Paraffin\|Western blot
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Polyclonal Antibodies/Phospho Specific, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	313 kDa
Manufacturer - Application Additional Information	IHC: 1:50~1:100; ELISA: 1:5000
Gene symbol	ITPR1
Gene Fullname	inositol 1, 4, 5-trisphosphate receptor type 1
Product format	Liquid
Reconstitution and storage	-20°C
Description of target	Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1, 4, 5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
Protein accession_num	NP_001093422.2
Protein name	Inositol 1, 4, 5-trisphosphate receptor type 1
Clonality	Polyclonal
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation.
Immunogen	The antiserum was produced against synthesized peptide derived from human IP3R1 around the phosphorylation site of Ser1764.
Dilution	The optimal working dilution should be determined by the end user.
Manufacturer - Specificity	IP3R1 (Phospho-Ser1764) antibody detects endogenous levels of IP3R1 only when phosphorylated at serine 1764.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/29/2026

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