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PIAS3 Antibody

PIAS3 Antibody

Item no.	OAAF01958
Manufacturer	AVIVA Systems Biology
Amount	100 ug
Category	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Adenocarcinoma Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Citations	Jiang-Hong Man, Nucleic Acids Res., Nov 2006; 34: 5552 - 5566. Amir Sonnenblick, Mol. Cell. Biol., Dec 2004; 24: 10584 - 10592. Jianyin Long, PNAS, Jan 2004; 101: 99. Hyun Duk Jang, J. Biol. Chem., Jun 2004; 279: 24873 - 24880.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	E3 SUMO-protein ligase PIAS3;E3 SUMO-protein transferase PIAS3;protein inhibitor of activated STAT protein 3;zinc finger,MIZ-type containing 5;ZMIZ5.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Applications	Enzyme-linked immunosorbent assay\|Immunofluorescence\|Immunohistochemistry\|Immunohistochemistry-Paraffin\|Western blot
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	68 kDa
Manufacturer - Application Additional Information	WB: 1:500~1:3000; IHC: 1:50~1:100; ELISA: 1:10000
Gene symbol	PIAS3
Gene Fullname	protein inhibitor of activated STAT 3
Product format	Liquid
Reconstitution and storage	-20°C
Description of target	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
Protein accession_num	NP_006090.2
Protein name	E3 SUMO-protein ligase PIAS3
Clonality	Polyclonal
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen	The antiserum was produced against synthesized peptide derived from human PIAS3.
Dilution	The optimal working dilution should be determined by the end user.
Manufacturer - Specificity	PIAS3 antibody detects endogenous levels of total PIAS3 protein.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 12/11/2025

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