B-Catenin Antibody (OAAH00021)

Catenin beta-1

1499

The catenins, a , B and, are proteins which bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. -catenin was initially described as an E-cadherin associated protein, and since has been shown to associate with other members of the cadherin family, such as Ncadherin and P-cadherin. -catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. -catenin has also been found in complexes with the tumor suppressor protein APC. -catenin, also known as plakoglobin, is a protein that binds with -catenin and N-cadherin. It has been shown that the transmembrane phosphatase PTP associates with catenin/cadherin complexes and may regulate complex signaling.

This Aviva monoclonal antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to carboxy-terminal residues of human Beta-catenin.