Anti-TGF- Beta R1 Polyclonal Antibody (OAAI00094)

TGFBR1

7046

Transforming growth factor beta isoforms (TGF-beta1, 2, 3) play vital roles in regulating cellular growth and differentiation, and they signal throμ gh a highly restricted subset of receptors known as TGF-beta type I receptor (TbetaR-I) and TGF-beta type II receptor(TbetaR-II). TGF-beta's specificity for TbetaR-I has been proposed to arise from its pre-helix extension, a five-residue loop that binds in the cleft between TGF-beta and TbetaR-II. TGF-beta binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain, which requires both its kinase activity and association with another TGF beta-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGF beta, and receptor II requires receptor I to signal. Mutations in TbetaR-I and TbetaR-II gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).

Polyclonal

A synthetic peptide derived from internal sequence (180-210aa) of Human TGFbeta receptor type-1. This sequence is also identical within Human, Rat, Mouse, chicken, bovine and dog species.