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Anti-C-erbB-2/HER-2 Antibody (OAAI00099)

Anti-C-erbB-2/HER-2 Antibody (OAAI00099)

Item no.	OAAI00099
Manufacturer	AVIVA Systems Biology
Amount	100 ug
Category	Oncology Neuroscience Neural Signaling Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Immunohistochemistry Western Blot Primary Antibodies Astrocytoma By Organ Lung Cancer Bladder Cancer Colorectal Cancer Breast Cancer
Type	Antibody Monoclonal
Applications	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	NEU, NGL, HER2, TKR1, CD340, HER-2, MLN 19, HER-2/neu
Similar products	MLN 19, HER2, NEU, NGL, CD340, HER-2, HER-2/neu, TKR1
Available
Gene symbol	ERBB2
Molecular weight	ca.185 kDa
Gene id	2064
Reconstitution and storage	The antibodies are stable for 12 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C to 8C for three month without detectable loss of activity. Avoid repeated freezing thawing cycles.
Description of target	Oncoprotein Her-2/Neu/ c-erbB-2 belongs to one of the four members of the ErbB receptor family. They are transmembrane receptor-like tyrosine kinases which can be autophosphorylated without ligand binding process when it is overexpressed in breast cancers. Her2 is an important biomarker in breast cancer diagnosis. The antibodies/ heregulin can suppress phosphorylation of HER2 on tyrosine Y1248. Endogenous anti-HER2 antibodies can effectively suppress HER2 kinase activity and downstream signaling to inhibit the transformed phenotype of HER2-expressing tumor cells. Thus, anti-Her2 antibodies have been used widely in the treatment of the breast cancer and other carcinomas.
Purification	The Mouse IgG is purified by Isotyping-specific Affinity Purification.
Clonality	Monoclonal
Immunogen	A synthetic peptide corresponding to the C-terminus of Her2 protein. This sequence is identical in Human, Mouse, and Rat.
Drywet	Wet Ice

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 9/25/2025

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