Anti-CXCR3 Monoclonal Antibody (OAAI00362)

ca.41 kDa

2833

Chemokine receptors are seven-transmembrane domain G-protein coupled receptors that mediate the biological activities of chemokines. Most of these receptors exhibit promiscuous binding properties whereby several different chemokines signal throμ gh the same receptor. They are named according to the chemokine subfamily they bind. There are currently six CXC-specific receptors designated CXCR1 to CXCR6. This Antibody recognizes surface expressed CXCR3, as judged by staining of CXCR3 transfected cells, but not untransfected cells. The Antibody also stained Human T cells and T cell clones that had been activated in vitro with PHA or anti-CD3. However, the anti-CXCR3 Antibody did not react with neutrophils. The CXCR3 receptor is also known as the IP-10 receptor and the Mig receptor.

Monoclonal

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