TACE Antibody

Item no.	OAPB00018
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Neural Adhesion Molecules Infectious Diseases Viral Infections Coronavirus (COVID-19) Antibodies By Cell Type Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Western Blot ELISA Immunofluorescence Immunocytochemistry Cardiovascular Research Heart Failure Myocardial Infarction Primary Antibodies Immunostaining Immunochemistry
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Conjugate/Tag	Unconjugated
Citations	Black RA, Rauch CT , Kozlosky CJ, et al. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature 1997;385:729-733 ;Moss ML, Jin SL, Milla ME, et al. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. Nature 1997;385:733-736;Mizui Y, Yamazaki K, Sagane K, Tanaka I. cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter. Gene 1999;233:67-74 ;Peschon JJ, Slack JL, Reddy P, et al. An essential role for ectodomain shedding in mammalian development. Science 1998;282:1281-4
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	a disintegrin and metalloproteinase 17;ADAM metallopeptidase domain 18;ADAM18;cartilage snake venom-like protease;CD156B;CSVP;disintegrin and metalloproteinase domain-containing protein 17;NISBD;NISBD1;snake venom-like protease;TACE;TNF-alpha convertase;TNF-alpha convertase enzyme;TNF-alpha converting enzyme;TNF-alpha-converting enzyme;tumor necrosis factor,alpha,converting enzyme.
Similar products	TACE
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	Predicted: 93kD Observed: 93-125kD (Post-modification: 9 N-linked glycosylation)
Manufacturer - Application Additional Information	TACE antibody can be used for detection of TACE by Western blot at 1:500 to 1:2000 dilution. 80 to 130 kDa bands can be detected, which may represent mature protein, precursor, and glycosylated TACE. (Optimal dilution should be determined by user)
Gene symbol	ADAM17
Gene Fullname	ADAM metallopeptidase domain 17
Product format	Liquid. TACE Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution and storage	TACE antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Description of target	Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
Protein accession_num	https://www.ncbi.nlm.nih.gov/protein/NP_003174
Protein name	Disintegrin and metalloproteinase domain-containing protein 17\|disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Anti-TACE antibody (1131) was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human TACE. The immunogen is located within the last 50 amino acids of TACE.
Homology	Human; Mouse; Rat
Concentration	1 mg/ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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