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NCSTN Antibody

NCSTN Antibody

Item no.	OAPB00467
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Adenocarcinoma Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining Neurodegeneration Markers
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Conjugate/Tag	Unconjugated
Citations	Weihofen A and Martoglio B. Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides. Trends Cell Biol. 2003; 13:71-8.; Periz G and Fortini ME. Functional reconstitution of g-secretase through coordinated expression of presenilin, Nicastrin, aph-1, and pen-2. J. Neurosci. Res. 2004; 77:309-22.;Selkoe DJ. The cell biology of b-amyloid precursor protein and presenilin in Alzheimerâ€™s disease. Trends Cell Biol. 1998; 8:447-53.;Nguyen V, Hawkins C, Bergeron C, et al. Loss of nicastrin elicits an apoptotic phenotype in mouse embryos. Brain Res. 2006; 1086:76-84.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	anterior pharynx-defective 2;ATAG1874;nicastrin.
Similar products	Nicastrin
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Applications	Enzyme-linked immunosorbent assay\|Immunofluorescence\|Immunohistochemistry-Paraffin\|Western blot
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Research Areas/Immunohistochemistry, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	Nicastrin antibody can be used for detection of Nicastrin by Western blot at 0.5 - 1 ug/ml. (Optimal dilution should be determined by user)
Gene symbol	NCSTN
Gene Fullname	nicastrin
Product format	Liquid. Nicastrin Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution and storage	Nicastrin antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Description of target	Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
Nucleotide accession_num	NM_001290184.1; NM_001290186.1; NM_015331.2
Protein accession_num	https://www.ncbi.nlm.nih.gov/protein/NP_056146
Protein name	Nicastrin\|nicastrin isoform 1 precursor [Homo sapiens]
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Nicastrin antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human Nicastrin. The immunogen is located within amino acids 630 - 680 of Nicastrin.
Homology	Human; Mouse; Rat
Concentration	1 mg/ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 2/12/2026

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