PTGDR2 Antibody

Item no.	OAPB00486
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg
Category	Oncology Neuroscience Molecular Targets for Neuroscience Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Status Adenocarcinoma Mesothelioma Immunohistochemistry Western Blot ELISA Immunofluorescence Autophagy Cardiovascular Research Proliferation Heart Failure Myocardial Infarction Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Conjugate/Tag	Unconjugated
Citations	Nagata K, Hirai K, Tanaka K, et al. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett. 1999; 459:195-9.;Shichijo M, Sugimoto H, Nagao K, et al. Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockage abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats. J. Pharmacol. Exp. Ther. 2003; 307:518-25.;Chevalier E, Stock J, Fisher T, et al. Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. J. Immunol. 2005; 2056-60. (07-01D) ;
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CD294;chemoattractant receptor homologous molecule expressed on T helper type 2 cells;chemoattractant receptor-homologous molecule expressed on TH2 cells;CRTH2;DL1R;DP2;GPR44;G-protein coupled receptor 44;prostaglandin D2 receptor 2;putative G-protein coupled receptor 44.
Similar products	CRTH2
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Applications	Enzyme-linked immunosorbent assay\|Immunofluorescence\|Immunohistochemistry-Paraffin\|Western blot
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Research Areas/Immunohistochemistry, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	CRTH2 antibody can be used for detection of CRTH2 by Western blot at 2 ug/ml. (Optimal dilution should be determined by user)
Gene symbol	PTGDR2
Gene Fullname	prostaglandin D2 receptor 2
Product format	Liquid. CRTH2 Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution and storage	CRTH2 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Description of target	Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
Nucleotide accession_num	NM_004778.2
Protein accession_num	https://www.ncbi.nlm.nih.gov/protein/NP_004769
Protein name	Prostaglandin D2 receptor 2\|prostaglandin D2 receptor 2 [Homo sapiens]
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	CRTH2 antibody was raised against a 15 amino acid synthetic peptide from near the center of human CRTH2. The immunogen is located within amino acids 220 - 270 of CRTH2.
Homology	Human; Mouse; Rat
Concentration	1 mg/ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 12/25/2025

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