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ORAI3 Antibody (OAPB00518)

ORAI3 Antibody (OAPB00518)

Item no.	OAPB00518
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg
Category	Antibodies Western Blot ELISA Immunocytochemistry Cardiovascular Research Myocardial Infarction Primary Antibodies
Type	Antibody Polyclonal
Applications	WB, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ORAI3 (NT), Transmembrane protein 142C, TMEM142C, Calcium release-activated calcium channel protein 3
Similar products	ORAI3
Available
Gene symbol	ORAI3
Protein name	Protein orai-3
Product format	Liquid. PBS containing 0.02% sodium azide
Gene id	93129
Reconstitution and storage	Product can be stored at 4° C for three months and -20° C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Description of target	Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter.
Purification	Affinity chromatography purified via peptide column
Clonality	Polyclonal
Immunogen	ORAI3 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human ORAI3. The immunogen is located within the first 50 amino acids of ORAI3.
Drywet	Wet Ice

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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OAPB00518-datasheet.pdf

OAPB00518-safety-datasheet.pdf