SCF Antibody

Polyclonal Antibody

Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Research Areas/Immunohistochemistry, Root Catalog/Products/Primary Antibodies

Predicted: 31kD Observed: 36 kD (31kD + 4 N-linked Glycosylations)

KITLG

Liquid. SCF Antibody is supplied in PBS containing 0.02% sodium azide.

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1, 4, 5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Polyclonal

Anti-SCF antibody (5165) was raised against a peptide corresponding to 18 amino acids near the center of human SCF. The immunogen is located within amino acids 100-150 of SCF.

1 mg/ml