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STAT1 Antibody

STAT1 Antibody

Item no.	OAAB17746
Manufacturer	AVIVA Systems Biology
Amount	400 ul
Category	Oncology Neuroscience Neural Lineage Markers Targets for Rodent Neurosciences Neural Signaling Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Immunoprecipitation Western Blot Primary Antibodies Astrocytoma Calcium Binding Protein Markers Interneuron Markers
Type	Antibody Monoclonal
Format	Liquid
Applications	WB
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Citations	Kristensen I., et al. Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. Schindler C., et al. Proc. Natl. Acad. Sci. U.S.A. 89:7836-7839(1992). Ota T., et al. Nat. Genet. 36:40-45(2004). Bechtel S., et al. BMC Genomics 8:399-399(2007). Kalnine N., et al. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	CANDF7,IMD31A,IMD31B,IMD31C,ISGF-3,STAT91
Similar products	STAT1, Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84
Shipping Condition	Cool pack
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	87 kDa
Manufacturer - Application Additional Information	WB: 1:1000
Gene symbol	STAT1
Product format	Liquid. Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Reconstitution and storage	Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Description of target	Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Protein accession_num	NP_009330.1, NP_644671.1
Clonality	Monoclonal
Purification	This antibody is purified through a protein G column, followed by dialysis against PBS.
Immunogen	Purified His-tagged STAT1 protein was used to produced this monoclonal antibody.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/27/2025

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