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Anti-ER- Beta Polyclonal Antibody (OAAI00255)

Anti-ER- Beta Polyclonal Antibody (OAAI00255)

Item no.	OAAI00255
Manufacturer	AVIVA Systems Biology
Amount	100 ug
Category	Oncology Food Safety Hormones Antibodies By Cell Type Carcinoma Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Erb, ESRB, ESTRB, NR3A2, ER-BETA, ESR-BETA
Similar products	Erb, ESRB, ESTRB, NR3A2, ER-BETA, ESR-BETA
Available
Gene symbol	ESR2
Molecular weight	53 kDa
Gene id	2100
Reconstitution and storage	The antibodies are stable for 12 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C to 8C for three month without detectable loss of activity. Avoid repeated freezing thawing cycles.
Description of target	ER (estrogen receptor) belongs to a member of the steroid receptor superfamily. It contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). The transcriptional effects of 17b-estradiol (E2) in the body are mediated by two distinct ERs, ER-alpha and ER-beta. ER-alpha plays an important role in differentiation by regulating target genes such as that for the progesterone receptor (PR). Both the stroma and epithelium express PR, and estrogen induces PR in the stromal and glandular epithelial cells. ER-alpha and ER-beta may have opposite effects on gene transcription. ER-beta can act as a transdominant repressor on ER-alpha transcriptional activity. ER-beta acts as a modulator of ER-alpha-mediated gene transcription in the uterus, and furthermore, that it is responsible for down regulation of PR in the luminal epithelium.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification.
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the c-terminus of Human Estrogen Receptor Beta.
Drywet	Wet Ice

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 10/9/2025

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