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Anti-Neurofibromin Antibody (Non-Phospho) (OAAI00706)

Anti-Neurofibromin Antibody (Non-Phospho) (OAAI00706)

Item no.	OAAI00706
Manufacturer	AVIVA Systems Biology
Amount	100 ug
Category	Oncology Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Immunoprecipitation Western Blot ELISA Primary Antibodies
Type	Antibody Polyclonal
Applications	WB, IP, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	WSS, NFNS, VRNF
Similar products	WSS, NFNS, VRNF
Available
Gene symbol	NF1
Molecular weight	240 kDa
Gene id	4763
Reconstitution and storage	The antibodies are stable for 12 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C to 8C for three month without detectable loss of activity. Avoid repeated freezing thawing cycles.
Description of target	The neurofibromatosis type 1 (NF1) tumor suppressor (neurofibromin) is thoμ ght to play crucial roles in cellular Ras- and cAMP-dependent kinase (PKA)-associated signals. The absence of or alteRation of the neurofibromin protein may lead to neurofibromatosis disease. Recently, a cellular neurofibromin-associating protein, NG, NG-dimethylarginine dimethylaminohydrolase (DDAH)has been identified as a cellular NO/NOS regulator which increases PKA phosphorylation of native neurofibromin in a dose-dependent manner. The PKA accessibility of neurofibromin regulated via DDAH interaction may modulate the cellular function of neurofibromin that is implicated in NF1-related pathogenesis.
Purification	The Rabbit IgG is purified by Site-specific Epitope Affinity Purification.
Clonality	Polyclonal
Immunogen	A synthetic peptide surrounding the epitope - PTSPY- without phosphorylation at Human neurofibromin. This sequence is identical among Human, Rat, Mouse, chicken, bovine and dog.
Drywet	Wet Ice

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 9/25/2025

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