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Anti-Notch 1 Polyclonal Antibody (OAAI00740)

Anti-Notch 1 Polyclonal Antibody (OAAI00740)

Item no.	OAAI00740
Manufacturer	AVIVA Systems Biology
Amount	100 ug
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Signaling Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Melanoma Sarcoma Immunohistochemistry Western Blot ELISA Primary Antibodies
Type	Antibody Polyclonal
Applications	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	hN1, TAN1
Similar products	hN1, TAN1
Available
Gene symbol	NOTCH1
Molecular weight	275 kDa
Gene id	4851
Reconstitution and storage	The antibodies are stable for 12 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C to 8C for three month without detectable loss of activity. Avoid repeated freezing thawing cycles.
Description of target	The 280-330kDa Notch protein is a single transmembrane receptor which is expressed on a range of cells including hematopoietic cells in Mouse fetal liver, adult thymus and bone marrow. These proteins have been found to be overexpressed or rearranged in Human tumors. It functions as a receptor for membrane-bound ligands Jagged1, Jagged-2 and Delta1 to regulate cell-fate determination. Following ligand binding, Notch 1 is cleaved in the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus, where it plays a role in the modulation of gene expression. Notch1 plays a role in embryonic development and tissue homeostasis in the adult. Recent work has sμ ggested a further role for this receptor in the regulation of lymphopoieisis and myelopoiesis.
Purification	The rabbit IgG is purified by Eptiope Affinity Purification.
Clonality	Polyclonal
Immunogen	A synthetic peptide derived from C-terminus of Human Notch 1.
Drywet	Wet Ice

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 9/25/2025

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