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SERPINE1 Antibody - Biotin Conjugated

SERPINE1 Antibody - Biotin Conjugated

Item no.	OACA01747
Manufacturer	AVIVA Systems Biology
Amount	100 ug
Category	Oncology Food Safety Proteins Antibodies Cell Biology Cell Status Western Blot ELISA Senescence Primary Antibodies By Organ Breast Cancer Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Biotin
Purity	Caprylic Acid Ammonium Sulfate Precipitation purified
Citations	[1] Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family.'Pannekoek H., Veerman H., Lambers H., Diergaarde P., Verweij C.L., van Zonneveld A.-J., van Mourik J.A.EMBO J. 5:2539-2544(1986) [2] Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns.'Loskutoff D.J., Linders M., Keijer J., Veerman H., van Heerikhuizen H., Pannekoek H.Biochemistry 26:3763-3768(1987) [3] cDNA cloning of human plasminogen activator-inhibitor from endothelial cells.'Ginsburg D., Zeheb R., Yang A.Y., Rafferty U.M., Andreasen P.A., Nielsen L., Dano K., Lebo R.V., Gelehrter T.D.J. Clin. Invest. 78:1673-1680(1986)
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	endothelial plasminogen activator inhibitor;PAI;PAI1;PAI-1;PLANH1;plasminogen activator inhibitor 1;serine (or cysteine) proteinase inhibitor,clade E (nexin,plasminogen activator inhibitor type 1),member 1;serpin E1;serpin peptidase inhibitor,clade E (nexin,plasminogen activator inhibitor type 1),member 1.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	SERPINE1
Gene Fullname	serpin family E member 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).
Protein name	Plasminogen activator inhibitor 1
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Plasminogen activator inhibitor 1 protein (24-398AA)
Storage Buffer	Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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