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BCL2 Antibody

BCL2 Antibody

Item no.	OAEE00023
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg (C100)
Category	Oncology Neuroscience Neuroinflammation Metabolism Cholesterol & Lipid Metabolism Neural Signaling Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Cell Biology Cell Movement Cell Adhesion Cell Culture Cytokines Cell Status Apoptosis Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot ELISA Immunofluorescence Immunocytochemistry Autophagy Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies By Organ Colorectal Cancer Testicular & Prostate Cancer Lymphatic System Cancer Immunochemistry
Type	Antibody Monoclonal
Applications	WB, FC, IP, IHC, ICC
Clone	Bcl2/100
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Purity	> 95% (by SDS-PAGE)
Citations	Gugasyan R, Christou A, O'Reilly LA, Strasser A, Gerondakis S: Bcl-2 transgene expression fails to prevent fatal hepatocyte apoptosis induced by endogenous TNFalpha in mice lacking RelA. Cell Death Differ. 2006 Jul;13(7):1235-7. Soilu-HÃ¤nninen M, Ekert P, Bucci T, Syroid D, Bartlett PF, Kilpatrick TJ: Nerve growth factor signaling through p75 induces apoptosis in Schwann cells via a Bcl-2-independent pathway. J Neurosci. 1999 Jun 15;19(12):4828-38. Joubert A, Marais S, Maritz C: Influence of 2-methoxyestradiol on MCF-7 cells: an improved differentialinterference contrasting technique and Bcl-2 and Bax protein expression levels. Biocell. 2009 Apr;33(1):67-70. Laflamme C, IsraÃ«l-Assayag E, Cormier Y: Apoptosis of bronchoalveolar lavage lymphocytes in hypersensitivity pneumonitis. Eur Respir J. 2003 Feb;21(2):225-31. Laforge M, Petit F, Estaquier J, Senik A: Commitment to apoptosis in CD4(+) T lymphocytes productively infected with human immunodeficiency virus type 1 is initiated by lysosomal membranepermeabilization, itself induced by the isolated expression of the viral protein Nef. J Virol. 2007 Oct;81(20):11426-40. And other.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	apoptosis regulator Bcl-2;B-cell CLL/lymphoma 2;Bcl-2;PPP1R50;protein phosphatase 1,regulatory subunit 50.
Similar products	Bcl2
Shipping Condition	Cool pack
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	Flow cytometry\|Immunocytochemistry\|Immunohistochemistry-Frozen\|Immunohistochemistry-Paraffin\|Immunoprecipitation\|Western blot
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	BCL2
Gene Fullname	BCL2 apoptosis regulator
Product format	Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Reconstitution and storage	2°C to 8°C
Description of target	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Nucleotide accession_num	NM_000633.2; NM_000657.2
Protein accession_num	NP_000624.2; NP_000648.2
Protein name	Apoptosis regulator Bcl-2
Clonality	Monoclonal
Purification	Purified
Immunogen	Synthetic peptide corresponding to the amino acids 41-54 of human Bcl2
Manufacturer - Specificity	The mouse monoclonal antibody Bcl2/100 recognizes Bcl2, a 26 kDa protooncogen with anti-apoptotic effect, expressed in outer mitochondrial membrane, endoplasmic reticulum and nuclear envelope.
Concentration	1 mg/ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg (C100)

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Delivery expected until 11/13/2025

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