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DBN1 Antibody

DBN1 Antibody

Item no.	OAEE00387
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg (C100)
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Molecular Targets for Neuroscience Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Flow Cytometry Western Blot Cardiovascular Research Atherosclerosis Primary Antibodies
Type	Antibody Monoclonal
Applications	WB, FC
Clone	DBN-N-03
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2b
Purity	> 95% (by SDS-PAGE)
Citations	Vaskova M, Kovac M, Volna P, Angelisova P, Mejstrikova E, Zuna J, Brdicka T, Hrusak O: High expression of cytoskeletal protein drebrin in TEL/AML1pos B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody. Leuk Res. 2011 Aug;35(8):1111-3. Epub 2011 Apr 16. PÃ©rez-MartÃnez M, GordÃ³n-Alonso M, Cabrero JR, Barrero-Villar M, Rey M, Mittelbrunn M, Lamana A, Morlino G, Calabia C, Yamazaki H, Shirao T, VÃ¡zquez J, GonzÃ¡lez-Amaro R, Veiga E, SÃ¡nchez-Madrid F: F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse. J Cell Sci. 2010 Apr 1;123(Pt 7):1160-70. Hayashi K, Ishikawa R, Kawai-Hirai R, Takagi T, Taketomi A, Shirao T: Domain analysis of the actin-binding and actin-remodeling activities of drebrin. Exp Cell Res. 1999 Dec 15;253(2):673-80. Hayashi K, Ishikawa R, Ye LH, He XL, Takata K, Kohama K, Shirao T: Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex. J Neurosci. 1996 Nov 15;16(22):7161-70. Sasaki Y, Hayashi K, Shirao T, Ishikawa R, Kohama K: Inhibition by drebrin of the actin-bundling activity of brain fascin, a protein localized in filopodia of growth cones. J Neurochem. 1996 Mar;66(3):980-8. Ishikawa R, Hayashi K, Shirao T, Xue Y, Takagi T, Sasaki Y, Kohama K: Drebrin, a development-associated brain protein from rat embryo, causes the dissociation of tropomyosin from actin filaments. J Biol Chem. 1994 Nov 25;269(47):29928-33.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	D0S117E;developmentally-regulated brain protein;drebrin;drebrin A;drebrin E;drebrin E2.
Similar products	Drebrin
Shipping Condition	Cool pack
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	Flow cytometry\|Mass cytometry\|Western blot
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	DBN1
Gene Fullname	drebrin 1
Product format	Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
Reconstitution and storage	2°C to 8°C
Description of target	Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.
Nucleotide accession_num	NM_004395.3; NM_080881.2; XM_005265827.2
Protein accession_num	NP_004386.2; NP_543157.1; XP_005265884.1
Protein name	Drebrin
Clonality	Monoclonal
Purification	Purified
Immunogen	Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)
Manufacturer - Specificity	The mouse monoclonal antibody DBN-N-03 recognizes drebrin, an approximately 100-125 kDa regulator of actin cytoskeleton.
Formulation	Purified
Concentration	1 mg/ml
Storage Buffer	Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg (C100)

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