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SLC9A3R1 Antibody

SLC9A3R1 Antibody

Item no.	OAEE00504
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg (C100)
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Aging & Neurological Disorders Antibodies By Cell Type Hematology Lymphoma Obesity Immunohistochemistry Immunoprecipitation Western Blot Cardiovascular Research Heart Failure Myocardial Infarction Hypertension Primary Antibodies Arrhythmias Neurodegeneration Markers
Type	Antibody Monoclonal
Applications	WB, IP, IHC
Clone	EBP-10
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2b
Purity	> 95% (by SDS-PAGE)
Citations	Lederer ED, Khundmiri SJ, Weinman E.J.: Role of NHERF-1 in regulation of the activity of Na-K ATPase and sodium-phosphate co-transport in epithelial cells. J Am Soc Nephrol. 2003 Jul;14(7):1711-9. Weinman EJ, Cunningham R, Wade JB, Shenolikar S.: The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a. J Physiol. 2005 Aug 15;567(Pt 1):27-32. Wheeler D, Sneddon WB, Wang B, Friedman PA, Romero G.: NHERF-1 and the cytoskeleton regulate the traffic and membrane dynamics of G protein-coupled receptors. J Biol Chem. 2007 Aug 24;282(34):25076-87. Morales FC, Takahashi Y, Momin S, Adams H, Chen X, Georgescu M.M.: NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZdomain ligands. Mol Cell Biol. 2007 Apr;27(7):2527-37. Kreimann EL, Morales FC, de Orbeta-Cruz J, Takahashi Y, Adams H, Liu TJ, McCrea PD, Georgescu M.M.: Cortical stabilization of beta-catenin contributes to HERF1/EBP50 tumor suppressor function. Oncogene. 2007 Aug 9;26(36):5290-9. Brdickova N, Brdicka T, Andera L, Spicka J, Angelisova P, Milgram SL, Horejsi V.: Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton. FEBS Lett. 2001 Oct 26;507(2):133-6.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	EBP50;ezrin-radixin-moesin binding phosphoprotein-50;Ezrin-radixin-moesin-binding phosphoprotein 50;Na(+)/H(+) exchange regulatory cofactor NHE-RF1;Na+/H+ exchange regulatory co-factor;NHERF;NHERF1;NHERF-1;NPHLOP2;regulatory cofactor of Na(+)/H(+) exchanger;Sodium-hydrogen exchanger regulatory factor 1;Solute carrier family 9 isoform A3 regulatory factor 1;solute carrier family 9,subfamily A (NHE3,cation proton antiporter 3),member 3 regulator 1.
Similar products	NHERF1 / EBP50
Shipping Condition	Cool pack
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	Immunohistochemistry-Paraffin\|Immunoprecipitation\|Western blot
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	SLC9A3R1
Gene Fullname	SLC9A3 regulator 1
Product format	Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Reconstitution and storage	2°C to 8°C
Description of target	Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.
Nucleotide accession_num	NM_004252.4
Protein accession_num	NP_004243.1
Protein name	Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Clonality	Monoclonal
Purification	Purified
Immunogen	Bacterially produced recombinant full-length human NHERF1.
Manufacturer - Specificity	The antibody EBP-10 reacts with NHERF1/EBP50 phosphoprotein of 50 kDa, which serves as an adaptor and regulator protein.
Formulation	Purified
Concentration	1 mg/ml
Storage Buffer	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg (C100)

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Delivery expected until 11/13/2025

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