CXCR4 antibody - N-terminal region

Polyclonal Antibody

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CXCR4

Liquid. Phosphate buffered saline

GOAT ANTI HUMAN CD184 (N-TERMINAL)

C-X-C chemokine receptor type 4

Synthetic peptide TEEMGSGDYDSMKEPCFREENANFNKC corresponding to amino acids 17-43 within the N-terminal region of human CD184 / CXCR4.

OASA06080 recognises an epitope within the N-terminal (NT) region of human CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1).
Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B- lymphopoiesis and myelopoiesis. CD184 is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates.
OASA06080 is reported as suitable for use in immunofluorescence studies.