Comparison

CD274 Antibody (OASA07586)

Item no. OASA07586
Manufacturer AVIVA Systems Biology
Amount 0.1mg
Category
Type Antibody Polyclonal
Format Purified IgG - liquid
Applications WB, IHC
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias B7-H, B7H1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, MGC142294, MGC142296, CD274
Similar products CD274
Available
Description
RABBIT ANTI HUMAN CD274
Short description
RABBIT ANTI HUMAN CD274
Gene symbol
CD274
Alias symbols
B7-H, B7H1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, MGC142294, MGC142296, CD274
Protein size
290
Gene_id
29126
Reconstitution and storage
Store at +4C or at -20C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Description of target
RABBIT ANTI HUMAN CD274
Specificity
OASA07586 detects CD274, also known as B7-H1 and PD-1L, a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to Interferons alpha, beta and gamma.

CD274 is reported to possess dual functions, inhibition of activated effector T cells and co-stimulation of naive T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1, PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to co-stimulate early T cell priming and differentiation.

Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection, as well as in many autoimmune diseases and cancers.
Homology short
Human
Immunogen
The immunogen for anti-CD274 antibody: a peptide corresponding to a 17 amino acid sequence from near the centre of Human CD274.
Application Info
Immunohistology - Paraffin: 2.5ug/ml Western Blotting: 0.5 - 1.0ug/ml OASA07586 detects a band of approximately 32kDa in Raji cell lysate.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 0.1mg
Available: In stock
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