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FGF1 Antibody (OACD03495)

FGF1 Antibody (OACD03495)

Item no.	OACD03495
Manufacturer	AVIVA Systems Biology
Amount	100ul
Category	Antibodies Immunohistochemistry Western Blot Immunocytochemistry Primary Antibodies
Type	Antibody Polyclonal
Applications	WB, IHC, ICC, IHC-P
Specific against	other
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Protein name	Fibroblast growth factor 1
Molecular weight	17 kDa
Product format	Liquid
Gene id	14164
Reconstitution and storage	Store at +4C. For long term storage, aliquot and store at -20C. Avoid freeze/thaw cycles.
Description of target	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.
Purification	Antigen-specific affinity chromatography
Clonality	Polyclonal
Formulation	PBS, pH7.4, containing 0.02% NaN3, 50% glycerol
Immunogen	Range: Phe16 - Asp155
Drywet	Wet Ice

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ul

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Delivery expected until 8/28/2025

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