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NEFH Antibody

NEFH Antibody

Item no.	OAEE00502
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg (C100)
Category	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot ELISA Immunocytochemistry Primary Antibodies Neurodegeneration Markers Glial Cell Markers Immunochemistry
Type	Antibody Monoclonal
Applications	WB, IHC, ICC
Clone	NF-01
Specific against	other
Host	Mouse
Isotype	IgG1
Purity	> 95% (by SDS-PAGE)
Citations	Lukas Z, Draber P, Bucek J, Draberova E, Viklicky V, Dolezel S: Expression of phosphorylated high molecular weight neurofilament protein (NF-H) and vimentin in human developing dorsal root ganglia and spinal cord. Histochemistry. 1993 Dec; 100(6):495-502. Cote F, Collard JF, Julien JP: Progressive neuronopathy in transgenic mice expressing the human neurofilamentheavy gene: a mouse model of amyotrophic lateral sclerosis. Cell. 1993 Apr 9;73(1):35-46. Ohara O, Gahara Y, Miyake T, Teraoka H, Kitamura T:Neurofilament deficiency in quail caused by nonsense mutation in neurofilament-L gene. J Cell Biol. 1993 Apr;121(2):387-95. Petzold A, Keir G, Warren J, Fox N, Rossor MN: A systematic review and meta-analysis of CSF neurofilament protein levels as biomarkers in dementia. Neurodegener Dis. 2007;4(2-3):185-94. Miyazawa I, Nakashima I, Petzold A, Fujihara K, Sato S, Itoyama Y: High CSF neurofilament heavy chain levels in neuromyelitis optica. Neurology. 2007 Mar 13;68(11):865-7. Wild EJ, Petzold A, Keir G, Tabrizi SJ: Plasma neurofilament heavy chain levels in Huntington's disease.Neurosci Lett. 2007 May 7;417(3):231-3.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	200 kDa neurofilament protein;CMT2CC;neurofilament heavy polypeptide;neurofilament triplet H protein;neurofilament,heavy polypeptide 200kDa;NFH;NF-H.
Similar products	Neurofilament heavy protein
Shipping Condition	Cool pack
Available
Specificity	Mammal
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	Immunocytochemistry\|Immunohistochemistry-Paraffin\|Western blot
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	NEFH
Gene Fullname	neurofilament heavy chain
Product format	Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Reconstitution and storage	2°C to 8°C
Description of target	Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.
Nucleotide accession_num	NM_021076.3
Protein accession_num	NP_066554.2
Protein name	Neurofilament heavy polypeptide
Clonality	Monoclonal
Purification	Purified
Immunogen	Pellet of porcine brain cold-stable proteins after depolymerization of microtubules.
Manufacturer - Specificity	The antibody NF-01 recognizes a phosphorylated epitope on heavy neurofilament protein (210 kDa) of various species. Antibodies to the various neurofilament subunits are very useful cell type markers since the proteins are among the most abundant of the nervous system, are expressed only in neurons and are biochemically very stable.
Formulation	Purified
Concentration	1 mg/ml
Storage Buffer	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg (C100)

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Delivery expected until 11/27/2025

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