« Back
Home /
Anti-Tyrosine Hydroxylase

Anti-Tyrosine Hydroxylase

Item no.	OAPC00077
Manufacturer	AVIVA Systems Biology
Amount	100 ul
Category	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Signaling Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies Dot Blot Neuronal Cell Markers
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, IHC, Dot
Specific against	Rat (Rattus norvegicus)
Host	Sheep
Citations	Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001) Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24:561-567. Salvatore MF, Waymire JC, Haycock JW (2001) Depolarization-stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situ. J Neurochem 79:349-360. Witkovsky P, Gabriel R, Haycock JW, Meller E (2000) Influence of light and neural circuitry on tyrosine hydroxylase phosphorylation in the rat retina. J Chem Neuroanat 19:105-116. Zhu MY, Klimek V, Haycock JW, Ordway GA (2000) Quantitation of tyrosine hydroxylase protein in the locus coeruleus from postmortem human brain. J Neurosci Meth 99:37-44. Zhu MY, Klimek V, Dilley GE, Haycock JW, Stockmeier C, Overholser JC, Meltzer HY, Ordway GA (1999) Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression. Biol Psychiatry 46:1275-1286.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	The
Shipping Condition	Cool pack
Available
Specificity	Rat, Most mammals, Some invertebrates
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Polyclonal Antibodies/Pan Specific, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	~60kDa
Manufacturer - Application Additional Information	DB: 1:1000IF: 1:1000IHC: 1:1000WB: 1:1000
Gene symbol	TH
Product format	Liquid10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug/ml BSA and 50% glycerol. Adequate amount of material to conduct 10 mini Western blots.
Reconstitution and storage	For long-term storage, -80C is recommended, but shorter-term storage at -20C is also acceptable as aliquots may be taken without freezing/thawing due to the presence of 50% glycerol. Stock solutions are stable for a minimum of one (1) year at -20C.
Description of target	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001).
Protein accession_num	NP_036872.1
Protein name	Tyrosine 3-monooxygenase
Clonality	Polyclonal
Purification	Affinity purified
Immunogen	Native rat tyrosine hydroxylase, purified from pheochromocytoma.
Homology	Most mammals, Some invertebrates
Manufacturer - Specificity	Specific for the ~60k tyrosine hydroxylase protein in Western blots of rat brain lysates and PC-12 cells stimulated by Okadaic acid. The antibody cross-reacts with all mammalian and at least some non-mammalian forms of the enzyme in WB and IF/IHC.
Concentration	0.15 mg/ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

OAPC00077-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 100 ul

available

Delivery expected until 1/29/2026

Express Delivery: Save 20 days

Compare

Add to wishlist

Get an offer