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PPP1R12A Antibody (Phospho-Thr853) (OASG04799)

PPP1R12A Antibody (Phospho-Thr853) (OASG04799)

Item no.	OASG04799
Manufacturer	AVIVA Systems Biology
Amount	100 uL
Category	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	WB, IHC
Specific against	other
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Gene symbol	PPP1R12A
Molecular weight	130 kDa
Product format	Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene id	4659; 17931; 116670
Reconstitution and storage	Store at -20° C, and avoid repeat freeze-thaw cycles.
Description of target	MYPT1 is a protein encoded by the PPP1R12A gene which is approximately 115, 2 kDa. MYPT1 is localised to the cytoplasm. It is involved in the activation of cAMP-dependent PKA, beta-adrenergic signalling, vascular smooth muscle contraction and actin nucleation by ARP-WASP complex. It regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho and is also a key regulator of protein phosphatase 1C. MYPT1 is expressed in striated muscles, specifically in type 2a fibres. Mutations in the PPP1R12A gene may result in infratentorial cancer and medullomyoblastoma. STJ90822 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous MYPT1 protein which only binds about T853 when T853 is phosphorylated.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality	Polyclonal
Immunogen	Synthesized peptide derived between 590-670aa from human MYPT1 around the phosphorylation site of T853.
Drywet	Wet Ice

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 uL

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