CDKN1A Antibody (OASG05487)

21 kDa

1026; 12575;

p21 is a protein encoded by the CDKN1A gene which is approximately 18, 1 kDa. p21 is localised to the cytoplasm and nucleus. It is involved in CDK-mediated phosphorylation and removal of Cdc6, RET signalling, cyclins and cell cycle regulation. It may be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. It binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. It also functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. Mutations in the CDKN1A gene may result in pancreatic cancer and ovarian cancer.

Polyclonal

Wet Ice