AHRR ELISA Kit (Human) (OKCD00574)

aryl hydrocarbon receptor repressor

57491

Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.2 Publications < p>Manually curated information for which there is published experimental evidence.< /p> < p>< a href="/manual/evidences#ECO:0000269">Moreâa‚¬A< /a>< /p> Manual assertion based on experiment iniRef.9"Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines."_x005F_x000D_ Haarmann-Stemmann T., Bothe H., Kohli A., Sydlik U., Abel J., Fritsche E._x005F_x000D_ Drug Metab. Dispos. 35:2262-2269(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.10"The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers."_x005F_x000D_ Zudaire E., Cuesta N., Murty V., Woodson K., Adams L., Gonzalez N., Martinez A., Narayan G., Kirsch I., Franklin W., Hirsch F., Birrer M., Cuttitta F._x005F_x000D_ J. Clin. Invest. 118:640-650(2008) [PubMed] [Europe PMC] [Abstract]Cited for: TISSUE SPECIFICITY, FUNCTION.

< 0.059 ng/mL