WWP2 ELISA Kit (Human) (OKCD01268)

NEDD4-like E3 ubiquitin-protein ligase WWP2

11060

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.2 Publications < p>Manually curated information for which there is published experimental evidence.< /p> < p>< a href="/manual/evidences#ECO:0000269">Moreâa‚¬A< /a>< /p> Manual assertion based on experiment iniRef.13"WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells."_x005F_x000D_ Xu H., Wang W., Li C., Yu H., Yang A., Wang B., Jin Y._x005F_x000D_ Cell Res. 19:561-573(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN UBIQUITINATION OF POU5F1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH POU5F1, MUTAGENESIS OF CYS-838.Ref.15"The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination."_x005F_x000D_ Chen A., Gao B., Zhang J., McEwen T., Ye S.Q., Zhang D., Fang D._x005F_x000D_ Mol. Cell. Biol. 29:5348-5356(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN UBIQUITINATION OF EGR2, INTERACTION WITH EGR2.

< 0.27 ng/mL