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RELA Peptide - middle region (AAP30371)

RELA Peptide - middle region (AAP30371)

Item no.	AAP30371
Manufacturer	AVIVA Systems Biology
Amount	100 ug
Category	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Molecular Targets for Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Neural Signaling Neural Epigenetics Peptides & Proteins Western Blot Peptides By Organ Bladder Cancer Neuronal Cell Markers Stem Cell Markers
Type	Peptides
Format	Lyophilized powder
Applications	WB
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	MGC131774, NFKB3
Similar products	RELA
Available
Description	This is a synthetic peptide designed for use in combination with anti-RELA antibody (Catalog #: ARP30371_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Gene symbol	RELA
Protein size	551
Molecular weight	60kDa
Product format	Lyophilized powder
Gene id	5970
Reconstitution and storage	Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Partner proteins	AES, BIRC3, CARM1, CCND1, CHEK1, CHUK, CREBBP, CREBBP, CXCL10, EGR1, EP300, EP300, FOS, IL8, ING4, JUN, NCOA3, NFKB1, NFKB1, NFKBIA, NFKBIA, NFKBIB, NFKBIB, SLC1A2, TERT, TLE1, AATF, ACTL6A, AES, AHR, AKAP8, APBA2, AR, BRCA1, BTK, BTRC, CALM1, CAMK4, CARM1, CDK9, CEBPB, CEBPD, CHEK1, CHUK, COMMD1, CREBBP, CSNK2A1, DDX1, DHX9, EGR1, EP300, ESR1, ETHE1, FAF1, FOS, FUS, GTF2B, HDAC1, HDAC2, HDAC3, HEXIM1, HMGA2, HMGB1, IKBKB, ING4, IRAK1BP1, IRF1, IRF2, IRF3, JUN, KAT2B, KPNA2, MAP2K6, MAP3K7, MAP3K8, MEN1, MST1R, MTPN, MYC, NCOA3, NCOR2, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NKRF, NKX2-1, NOTCH1, NR3C1, PARP1, PDCD11, PGR, PIAS1, PIAS3, PIN1, PML, POU2F1, PPARA, PPP1R13L, PPP2CA, PPP2R1B, PPP4C, PRKACA, PRKCZ, PRTN3, REL, RELA, RELB, REPS2, RFC1, RNF25, RPS6KA5, RXRA, SIRT1, SNIP1, SOCS1, SP1, SRF, STAT1, STAT3, STAT6, TAF1, TAF11, TAF4B, TAF6, TBK1, TBP, TERT, TNIP2, TP53BP1, TP53BP2, TRIB3, TRIP4, TSC22D3, TWIST1, UNC5CL, AES, AHR, AKAP8L, APBA2, ASCC1, ASCC2, ASCC3, BARD1, BRCA1, BTRC, CDK9, CEBPB, CEBPD, COMMD1, CREBBP, CSNK2A1, CSNK2A2, DHX9, EGR1, EP300, ETHE1, FOS, FUS, GTF2B, HDAC1, HDAC2, HDAC3, HEXIM1, HMGA2, HMGB1, Hdac1, ING4, IQGAP2, IRF2, IRF8, IRF9, ITGB3BP, JUN, KDM2A, KPNA2, MAP3K8, MEN1, MTPN, MYC, NCF1, NCOA6, NCOR2, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NKRF, NKX2-1, NOTCH1, NR3C1, NSD1, PARP1, PDLIM2, PGR, PIAS3, PML, POU2F1, PPARA, PPP1R13L, PPP2CA, PPP2CB, PPP4C, PRKCZ, REL, RELA, RELB, RFC1, RNF25, RXRA, SOCS1, SP1, SRF, STAT3, TAF1, TAF11, TAF4B, TAF6, TBK1, TBP, TERT, TLE1, TNIP2, TRIB3, TWIST1, UBC, UNC5CL
Description of target	p65 is a subunit of the nuclear factor kappa-B, a second messenger, which activates the transcription of a number of genes in multiple tissues. The inhibitory effect of I-kappa-B upon NF-kappa-B in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1760 M62399.1 8-1767

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 10/30/2025

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