SH3BP2 Protein Lysate (APL10217)

SH3BP2

53

Add 200ul of distilled water. Final concentration is 1 mg/ml. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.

The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.