Eotaxin Protein

Root Catalog/Products/Recombinant Proteins

8345.9 Da

EOTAXIN

Lyophilized from 0.2um filtered concentrated (1.0 mg/ml) solution in 20mM PB, pH 7.4, 150mM NaCl
Physical Appearance: Sterile filtered white powder

Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17.

Eotaxin

The activity is determined by the chemoattract of human PBE (peripheral blood eosinophils) at a concentration between 0.1-10 ng/ml corresponding to a Specific Activity of 100, 000 - 10, 000, 000 IU/mg