TWEAK Receptor Protein (OPPB00214)

TWEAKR belongs to the TNF family of transmembrane proteins and contains a cytoplasmic 'death domain', which can activated the cell's apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAKR can be activated by either the membrane anchored or the soluble TWEAK. Recombinant soluble TWEAKR is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAKR protein.

Preparation: Biological activity was determined by its ability to inhibit TWEAK - induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0 - 3.0 ug/ml.Storage: The lyophilized TWEAK Receptor recombinant protein is stable for at least 2 years from date of receipt at -20C. Reconstituted TWEAK Receptor is stable for at least 3 months when stored in working aliquots with a carrier protein at -20C. As with any protein, exposing TWEAK Receptor recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.