Vitronectin Protein (OPPB00434)

Vitronectin is a secreted glycoprotein which is synthesized in the liver. It circulates primarily in monomeric form, but can undergo conformational change to a structure that forms disulfide linked multimers. The multimeric Vitronectin can efficiently bind to and incorporate into the extracellular matrix. Within the matrix, Vitronectin can support cell adhesion through binding to various integrins and other proteoglycans. Additionally, recombinant vitronectin can function as a chemically defined matrix component in human embryonic stem cell renewal media. Recombinant human Vitronectin is a 459 amino acid single chain monomeric protein, which migrates at an apparent molecular weight of 75 kDa by SDS-PAGE under reducing conditions.

Preparation: Endotoxin level is less than 0.1 ng per ug (1EU/ug).Storage: The lyophilized Vitronectin recombinant protein is stable for at least 2 years from date of receipt at -20C. Reconstituted Vitronectin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20C. As with any protein, exposing Vitronectin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.