Fibronectin Fragment (1376-1380)

The short peptide PHSRN has been identified in the 9th type III fibronectin repeat as a key site for synergistic enhancement of the cell-adhesive activity of the RGD sequence in the 10th type III repeat. However, this synthetic peptide mediated a synergistic enhancement of cell-adhesive activity only when it was covalently linked to the corresponding site of a non-active recombinant construct consisting of the 8th and 10th type III fibronectin repeats. Miyamoto et al. observed that PHSRN ameliorates the inhibitory effects of conventional peritoneal dialysis fluids on peritoneal wound healing.