Nuclear Factor NF-KB Inhibitor SN50

Nuclear Factor NF-KB Inhibitor SN50 is a cell-permeable nuclear translocation inhibitor of the transcription factor NF-KB. It consists of the hydrophobic region (h-region) of the Kaposi fibroblast growth factor (K-FGF) signal sequence which mediates the cellular import of this peptide and the nuclear localization signal (NLS) of the NF-KB p50 subunit. The peptide inhibited nuclear translocation of NF-KB in LPS- or TNF-alpha-stimulated murine endothelial LE-II and human monocytic THP-1 cells. In several cell lines SN50 interfered with NF-KB-mediated pro-apoptotic events such as caspase-3 activation.