Anti-Human CD28 APC

Item no.	10311-80-25
Manufacturer	BioGems
Amount	25 tests
Category	Neuroscience Neural Lineage Markers Aging & Neurological Disorders Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Primary Antibodies
Type	Antibody
Format	APC
Applications	FC, IP, IHC
Clone	CD28.2
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Conjugate/Tag	APC
Citations	Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York Nunas, J., Klasen, S., Ragueneau, M., Pavon, C., Couez, D., Mawas, C., ... & Olive, D. (1993). CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events.International immunology, 5(3), 311-315. Karlsson, I., Malleret, B., Brochard, P., Delache, B., Calvo, J., Le Grand, R., & Vaslin, B. (2007). FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load. Journal of virology, 81(24), 13444-13455.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes. CD28 is a ligand for B7-1 (CD80) and B7-2 (CD86), a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes. It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 molecule presents some subregions with distinct functions. The CD28.2 antibody induces Ca2+ influx in Jurkat T lymphocytes. Other studies have shown that CD28 is involved in the signal transduction.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ph7.2.
Preperation	The product should be stored undiluted at 4C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µ g of the protein.
Research Interest	Adaptive Immunity

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10311-80-25-datasheet.pdf

10311-80-25-safety-datasheet.pdf