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Anti-Mouse CD18 SAFIRE Purified

Anti-Mouse CD18 SAFIRE Purified

Item no.	10212-25-50
Manufacturer	BioGems
Amount	50 ug
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Aging & Neurological Disorders Antibodies Flow Cytometry Primary Antibodies By Organ Skin Cancer
Type	Antibody
Format	SAFIRE Purified
Applications	FC
Clone	M18/2
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2a Kappa
Citations	Driessens, M. H., Van Hulten, P., Zuurbier, A., La Riviere, G., & Roos, E. (1996). Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1,-2, and-3 are distinct. Journal of leukocyte biology, 60(6), 758-765. Zahalka, M. A., & Naor, D. (1994). β2-lntegrin dependent aggregate formation between LB T cell lymphoma and spleen cells: assessment of correlation with spleen invasiveness. International immunology, 6(6), 917-924. Isobe, M., Yagita, H., Okumura, K., & Ihara, A. (1992). Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science,255(5048), 1125-1127.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The M18/2 monoclonal antibody specifically binds to mouse CD18, a 95kDA integrin beta 2 glycoprotein. CD18 is expressed on all leukocytes with the highest density by NK and T cells. CD18 forms LFA-1 with CD11a, Mac-1 with CD11b and gp150/95 with CD11c. Through these interactions, CD18 has an important role in cellular adhesion. The M18/2 antibody is reported to stimulate Mac-1 and LFA-1 adhesion to their ligands and block tumor cell metastasis.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ph7.2.
Preperation	The product should be stored undiluted at 4C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µ g of the protein.
Research Interest	Angiogenesis
Format	SAFIRE Purified

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

10212-25-50-datasheet.pdf

10212-25-50-safety-datasheet.pdf