CaMKIIα/β/δ (phospho Thr305) Polyclonal Antibody

Ice packs

1 year

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Calcium/calmodulin dependent protein kinase II beta belongs to the serine/threonine protein kinase family and to the Ca (2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of CAMK2B is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB: 1:500-1:2000, IHC-p: 1:100-1:300, ELISA: 1:5000. Not yet tested in other applications.