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Native Human Serum Aminopeptidase N (ANPEP)

Native Human Serum Aminopeptidase N (ANPEP)

Item no.	BTZ-30801003
Manufacturer	BioTeZ
Amount	200 ug/1 ml
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Molecular Targets for Neuroscience Hematology Leukemia Peptides & Proteins Native Proteins
Type	Proteins Native
Format	Liquid
Specific against	Human (Homo sapiens)
Protein Family	Aminopeptidase
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Purity	>90%
Product Subcategory	EC 3.4.11.2
Pathway and Disease	Diseases associated with ANPEP include Tetrasomy 21 and Acute Leukemia. Among its related pathways are Hematopoietic cell lineage and Transport to the Golgi and subsequent modification
Description	ANPEP plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
Applications Info	Screening of inhibitors, Characterization of structure and function, Target for angiogenesis
Alternate Names	ANPEP; Myeloid Plasma Membrane Glycoprotein CD13, Membrane Alanyl Aminopeptidase
Sequence	MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQ EKNKNANSSPVASTTPSASATTNPASATTLDQSKA WNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKG SSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLR GVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQ YEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATT QMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTA LSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLL AFIVSEFDYVEKQASNGVLI RIWARPSAIAAGHG DYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDF NAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVT VIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEY LGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHP LSTPASEINTPAQISELFDAISYSKGASVLRMLSS FLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEA VNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTG TLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDG RQQQDY WLIDVRAQNDLFSTSGNEWVLLNLNVTG YYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIIN DAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAA LSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHF RNNTNNWREIPENLMDQYSEVNAISTACSNGVPEC EEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQ GGEEEWDFAWEQFRNATLVNEADKLRAALACSKEL WILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQ GLVWDFVQSNWKKLFNDYGGGSFSFSN LIQAVTR RFSTEYELQQLEQFKKDNEETGFGSGTRALEQALE KTKANIKWVKENKEVVLQWFTENSK
Accession No	P15144
Composition	20 mM Tris-HCl, pH 7.4, 500 mM NaCl, 1mM CaCl2
Storage	Store at -70C
Target Modification	Yes
Expression System	Human Serum
Product Subtype	full length
Active?	Yes
Tag	untagged
Gene ID	290
Molecular Weight	110-130 kDa
Shipping Temp Min	dry ice
Product description long	Aminopeptidase N is prepared from human serum certified to be negative for HBsAg and for antibodies to HIV and HCV.
Purification	Mentioned in the data sheet
Restrictions	For Research Use only.
NCBI Official Symbol	ANPEP

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 200 ug/1 ml

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Delivery expected until 10/30/2025

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