PPP4R1 polyclonal antibody

Q8TF05

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Protein phosphatase 4 (PP4) is comprised of different regulatory subunits that exhibit mutually exclusive interactions with the PP4 catalytic subunit, PPX. PP4R1, also known as PPP4R1 or PP4(Rmeg), is regulatory subunit 1 of protein phosphatase 4. It is ubiquitously expressed and can form a binary complex with PPX that negatively regulates the activity of HDAC3. PP4 is required for cell growth, nucleation and the stabilization of microtubules during cell division. This suggests that PP4R1 participates in the regulation of mitosis.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

PPP4R1 pAb detects endogenous levels of PPP4R1 protein.

ca. 107 kDa

Serine/threonine-protein phosphatase 4 regulatory subunit 1, PPP4R1, MEG1, PP4R1