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PPAR-gamma (C-terminus) monoclonal antibody

PPAR-gamma (C-terminus) monoclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Neural Mitochondrial Function Neural Signaling Antibodies Immunohistochemistry Western Blot Cardiovascular Research Atherosclerosis Primary Antibodies Other Lipid\Cholesterol Metabolism Modulators
Type	Antibody Monoclonal
Specific against	Human
Applications	WB, IHC
Amount	50ul
Host	Mouse
Item no.	MB0080-50
Targets	PPARA ;;PPARG
eClass 6.1	32160702
eClass 9.0	42030590
Available
Swiss-Prot	P37231
Application all	WB: 1:1000
Background	PPAR gamma is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPAR gamma may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPAR gamma2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPAR gamma2 gene maybe correlated with abdominal obesity in type 2 diabetes.
Product	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%, glycerol
Purification and Purity	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	This antibody detects endogenous levels of PPAR gamma (C-terminus) and does not cross-react with related proteins
WB	Western blot detection of PPAR gamma antibody in 3T3-L1&Mouse Lung cell lysates using PPAR gamma antibody (1:1000 diluted) .
BiowMW	Predicted band size:54KDa Observed band size:54KD
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	Peroxisome proliferator-activated receptor gamma, Short name=PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, PPARG, NR1C3, PPAR gamma, PPARgamma
Immunogen	Synthetic peptide, corresponding to amino acids C-terminus of Human PPAR-gamma.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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