Integrin beta3 (N-terminus) monoclonal antibody

P05106

Integrins are heterodimers composed of noncovalently associated transmembrane alpha and beta subunits. The 16alpha and 8beta subunits heterodimerize to produce more than 20 different receptors. Most Integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain Integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster Integrins by binding to adjacent Integrin receptors, both receptor clustering and ligand occupancy are necessary for the activation of Integrinmediated responses.

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

This antibody detects endogenous levels of Integrin beta3 and does not cross-react with related proteins

Predicted band size :87KDa
Observed band size:110KDa

Integrin beta-3, Platelet membrane glycoprotein IIIa, Short name=GPIIIa, CD_antigen=CD61, ITGB3, GP3A, CD61, GPIIIa