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PPAR-gamma (I106) polyclonal antibody

PPAR-gamma (I106) polyclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Antibodies Immunohistochemistry Western Blot Cardiovascular Research Atherosclerosis Primary Antibodies Other Lipid\Cholesterol Metabolism Modulators
Type	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Applications	WB, IHC
Amount	100ul
Host	Rabbit
Item no.	BS1587-100
Targets	PPARA ;;PPARG
eClass 6.1	32160702
eClass 9.0	32160702
Available
Swiss-Prot	P37231
Application all	WB: 1:500ca.1:1000 IHC: 1:50ca.1:200
Background	PPAR gamma is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPAR gamma may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPAR gamma2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPAR gamma2 gene maybe correlated with abdominal obesity in type 2 diabetes.
Product	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	PPAR-gamma (I106) pAb detects endogenous levels of PPAR-gamma protein .
WB	Western blot (WB) analysis of PPAR-gamma (I106) pAb at 1:500 dilution Lane1:HEK293T cell lysate Lane2:Raw264.7 cell lysate Lane3:PC12 cell lysate
IHC	Immunohistochemistry (IHC) analyzes of PPAR-gamma (I106) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.
BiowMW	ca. 54 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	Peroxisome proliferator-activated receptor gamma, Short name=PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, PPARG, NR1C3, PPAR gamma, PPARgamma
Immunogen	Synthetic peptide, corresponding to amino acids 90-120 of Human PPAR-gamma.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ul

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