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Epsin 2 (L304) polyclonal antibody

Epsin 2 (L304) polyclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Applications	WB
Amount	100ul
Host	Rabbit
Item no.	BS3122-100
eClass 6.1	32160702
eClass 9.0	32160702
Available
Swiss-Prot	O95208
Application all	WB: 1:500ca.1:1000
Background	Elucidation of the mechanism by which receptor tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli is critical to the understanding of growth regulation. Miscues in RTK signaling pathways can result in cellular transformation and ultimately in cancer. Two novel EGF receptor substrates designated EGF-receptor pathway substrates 8 and 15, or Eps8 and Eps15, have been described. Epsin is a 90 kDa binding partner to Eps15. Both epsin and Eps15 have an ubiquitous tissue distribution but are concentrated in presynaptic nerve terminals specialized for the Clathrin-mediated endocytosis of synaptic vesicles. Disruption of epsin function blocks Clathrinmediated endocytosis. Epsin along with its binding partner Eps15 is proposed to be involved in the assistance of Clathrin coat rearrangement during Clathrin coated pit invagination. Epsin 2 and epsin 2a are also associated with Clathrin-mediated endocytosis and are enriched in the brain in the peri-Golgi region.
Product	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	Epsin 2 (L304) pAb detects endogenous levels of Epsin 2 protein.
WB	Western blot (WB) analysis of Epsin 2 (L304) pAb at 1:500 dilution Lane1:Hela cell lysate Lane2:sp2/0 cell lysate Lane3:PC12 cell lysate
BiowMW	ca. 68 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	Epsin-2, Epsin2, EPS-15-interacting protein 2, EPN2, KIAA1065
Immunogen	Synthetic peptide, corresponding to amino acids 271-320 of Human Epsin 2.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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