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APP/beta-Amyloid (phospho-T668) polyclonal antibody

APP/beta-Amyloid (phospho-T668) polyclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Applications	WB, IHC
Amount	100ul
Host	Rabbit
Item no.	BS4214-100
Targets	APP
eClass 6.1	32160702
eClass 9.0	32160702
Available
Swiss-Prot	P05067
Application all	WB: 1:500ca.1:1000 IHC: 1:50ca.1:200
Background	Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the beta-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer's disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the Amyloid beta/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer's patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP.
Product	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	p-APP/beta-Amyloid (T668) pAb detects endogenous levels of APP695 protein only when phosphorylated at Thr668 (or the corresponding position on other isoforms).
WB	Western blot (WB) analysis of p-APP/beta-Amyloid (T668) pAb at 1:500 dilution Lane1:MCF-7 cell lysate treated with colchicine Lane2:Mouse liver tissue lysate Lane3:Rat liver tissue lysate
IHC	Immunohistochemistry (IHC) analyzes of p-APP/beta-Amyloid (T668) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.
BiowMW	ca. 70 to140 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	Amyloid beta A4 protein, ABPP, APPI, Short name=APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, Short name=CVAP, PreA4, Protease nexin-II, Short name=PN-II, N-APP, Soluble APP-alpha, Short name=S-APP-alpha, Soluble APP-beta, Short name=S-APP-beta, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, P3(42), P3(40), Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, Short name=AICD-59, Short name=AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, Short name=AICD-57, Short name=AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), APP, A4, AD, Amyloid-beta, Amyloid beta, Amyloidbeta, beta Amyloid, betaAmyloid, Abeta
Immunogen	Synthetic phosphopeptide derived from human APP/beta-Amyloid around the phosphorylation site of Threonine 668.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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