PIK3C2G polyclonal antibody

O75747

Phosphoinositide 3-kinase activity is implicated in assorted cellular responses activated by mammalian cell surface receptors and the regulation of protein sorting in yeast. The p110gamma (PIK3CG) enzyme is activated in vitro by both the alpha and betagamma subunits of heterotrimeric GTP-binding proteins (G proteins) and does not associate with a p85 adaptor molecule. PI 3-kinase C2gamma, also designated p110gamma, may link signaling through G protein-coupled receptors to the generation of phosphoinositide second messengers that are phosphorylated in the D-3 position. The PI 3-kinase C2gamma gene encodes a 1, 050 amino acid polypeptide with 36% identity to human PI 3-kinase C2alpha. Research indicates that PI 3-kinase C2gamma can block the growth of human colon cancer cells.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

PIK3C2G pAb detects endogenous levels of PIK3C2G protein.

ca. 171 kDa

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma, PI3K-C2-gamma, Short name=PtdIns-3-kinase C2 subunit gamma, Phosphoinositide 3-kinase-C2-gamma, PI 3-kinase C2gamma, PI3KC2gamma