Anti-Caspase-9 CASP9 Antibody

Primary Antibodies

46281 MW

WB: 1 μg/mL; ICC: 2- 5 μg/mL; IF: 5-20 μg/mL.
Antibody validated: Western Blot in human and mouse samples, Immunocytochemistry, Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Caspase 9, apoptosis-related cysteine peptidase

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα , TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

Caspase-9 Antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/mL

Caspase 9, apoptosis-related cysteine peptidase

Nucleus

Ubiquitous, with highest expression in the
heart, moderate expression in liver, skeletal muscle, and
pancreas. Low levels in all other tissues. Within the heart,
specifically expressed in myocytes.

Caspase-9 antibody is predicted to have no cross reactivity to other members in the caspase family.