Anti-FGFR2 Antibody

Primary Antibodies

92025 MW

IHC: 1:50-1:200

Fibroblast growth factor receptor 2

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Tyrosine-protein kinase that acts as cell-surface
receptor for fibroblast growth factors and plays an essential role
in the regulation of cell proliferation, differentiation,
migration and apoptosis, and in the regulation of embryonic
development. Required for normal embryonic patterning, trophoblast
function, limb bud development, lung morphogenesis, osteogenesis
and skin development. Plays an essential role in the regulation of
osteoblast differentiation, proliferation and apoptosis, and is
required for normal skeleton development. Promotes cell
proliferation in keratinocytes and immature osteoblasts, but
promotes apoptosis in differentiated osteoblasts. Phosphorylates
PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of
several signaling cascades. Activation of PLCG1 leads to the
production of the cellular signaling molecules diacylglycerol and
inositol 1, 4, 5-trisphosphate. Phosphorylation of FRS2 triggers
recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates
activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase
signaling pathway, as well as of the AKT1 signaling pathway. FGFR2
signaling is down-regulated by ubiquitination, internalization and
degradation. Mutations that lead to constitutive kinase activation
or impair normal FGFR2 maturation, internalization and degradation
lead to aberrant signaling. Over-expressed FGFR2 promotes
activation of STAT1.

Boster Bio Anti-FGFR2 Antibody catalog # A00231-1. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.